Prajña Press published works on Buddhist studies, including translations and commentaries on Buddhist texts. Some of their titles include The Cultural Heritage of Ladakh (Snellgrove and Skorupski 1977), Glimpses of Abhidharma (Trungpa 1978), The Laṅkāvatāra Sūtra (Suzuki 1978), Lucid Exposition of the Middle Way (Sprung 1979), The History of the Sixteen Karmapas of Tibet (Thinley 1980) Journey Without Goal: The Tantric History of Tibet (Trungpa 1981), and Himalayan Pilgrimage (Snellgrove 1981.)
The press was focused on disseminating knowledge on Buddhism, particularly Mahayana and Tibetan Buddhism, as well as cultural and historical aspects of Tibet.